The Lovers, Wives, and Neighbors of Infamous Killers

Diana Morales · July 28, 2026

Nannie Doss – The “Giggling Granny” Who Poisoned Her Husbands

Nannie Doss was a cheerful, smiling woman who loved reading romance magazines and sharing jokes. She was also a serial killer who poisoned four of her five husbands, along with several family members. Her cheerful demeanor earned her the nickname “The Giggling Granny.” Neighbors and friends never suspected her, believing she was just unlucky in love after each husband’s sudden death. Only later did investigators uncover her deadly pattern. Doss confessed with a smile, showing no remorse for her crimes. Her story horrified the public, who couldn’t reconcile her grandmotherly appearance with her murderous deeds. She remains one of the most infamous female killers in American history.